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Senior Scientist, Core Antisense Research

Carlsbad, CA

Ionis Pharmaceuticals, Inc., is headquartered in Carlsbad, California, with offices in Boston, Massachusetts, and Dublin, Ireland. For more than 30 years, Ionis has been the leader in RNA-targeted therapy, pioneering new markets and changing standards of care with our novel antisense technology. Ionis currently has three marketed medicines and a premier late-stage pipeline highlighted by industry-leading cardiovascular and neurological franchises.

Our scientific innovation began and continues with the knowledge that sick people depend on us, which fuels our vision to become the undisputed leader in genetic medicine, utilizing a multi-platform approach to discover, develop and deliver life-transforming therapies.

As the first company to fully harness the power of RNA technology for human therapeutics, Ionis’ platform continues to revolutionize drug discovery and transform lives for patients with unmet needs. We are building upon our innovative research and drug development excellence to provide greater value to patients, and we are well positioned financially to deliver on our strategic goals.

Ionis is a challenging, motivating and rewarding environment designed to foster innovation and scientific excellence. Our success is a direct result of our outstanding employees. We are interested in bringing together a diverse group of individuals with different skill sets and perspectives into this creative environment to be part of a productive and inclusive team. While acknowledging people are actively engaged in hybrid/remote work, we continue to invest time, money, and energy into making our workplace locations a place where our culture and employees can thrive. We believe engaging on a day-to-day basis, in person, builds solid and lasting relationships, and contributes positively to our culture and innovation. 

From the heart of our stunning Carlsbad campus, we aim to provide a central connection point for all our employees. These facilities give us the opportunity to connect cross-functionally, collaborate and to build on the success of our business as we continue to grow.  Join us and experience our unique culture while you develop and expand your career.

We are seeking a highly qualified and motivated individual to join our Core Antisense Research Group. This position offers the opportunity to do groundbreaking science and make discoveries that will create the next generation of nucleic acid-based medicines. The successful candidate will be responsible for leading innovative research projects and will become an integral part of an interdisciplinary and energetic team of scientists.


  • Ph.D. in biochemistry or molecular biology with a focus on RNA biology or gene regulation
  • Experience with advanced laboratory techniques such as ChIP-seq, RNA-seq, CLIP-seq, SHAPE-seq, and CRISPR editing
  • Proven track record of innovative research, including publications in top tier scientific journals
  • Self-starter who is a critical thinker, has a strong work ethic and not afraid to take risks
  • Outstanding organizational, communication and team skills
  • Ability to be productive and successful in an intense work environment

Ionis offers an excellent benefits package! Follow this link for more details: Ionis Benefits

The pay scale for this position is $118,072 to $145,889


Ionis Pharmaceuticals, Inc. and all its subsidiaries are proud to be EEO employers.

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