Senior Engineer

Thousand Oaks, CA +1


You’ve worked hard to become the professional you are today and are now ready to take the next step in your career. How will you put your skills, experience and passion to work toward your goals? At Amgen, our shared mission—to serve patients—drives all that we do. It is key to our becoming one of the world’s leading biotechnology companies, reaching over 10 million patients worldwide. Come do your best work alongside other innovative, driven professionals in this meaningful role.


What you will do

Let’s do this. Let’s change the world.

Amgen's Combination Product Operations Digital and Data Strategies group is a process development team that develops and deploys state of the art advanced computational technologies and empirical and first principles models towards improved process understanding, robustness and monitoring, and prediction and optimization of the manufacturing of combination products. 

We are seeking a Senior Engineer – Modeling and Simulation to support the team by developing and deploying rigorous computational models (in-silico modeling assets) of drug delivery device technologies and improving the way Amgen manages and utilizes in-silico models to enhance decision making within the organization.

The candidate will apply in-silico modeling theory to develop novel mechanistic computational models (virtual combination products) addressing a wide variety of challenging problems associated with combination product design control, characterization, verification, and validation.

The ideal candidate enjoys tackling challenges and excels at developing functional in-silico models of combination products that enable insights for root cause investigation and design robustness supporting lifecycle management activities and complaint reduction. 


  • Identifying requirements and specifications suitable for in-silico evaluation of combination products.
  • Applying finite element analysis (FEA) and engineering simulation principles to develop, deploy, enhance, automate, and manage in-silico models for combination products.
  • Implementing in-silico models in commercial and proprietary software and deploying these models to internal users via enterprise modeling infrastructure.
  • Demonstrating critical and analytical thinking skills to explore new opportunities in in-silico and data-driven computational models and simulate complaints and real-world issues within lifecycle of combination products.
  • Providing positive leadership and delivering work in a fast-paced, multi-project, cross-functional environment.
  • Product ownership, responsible for developing and managing backlog of in-silico product content in Scrum and SAFe (Scale Agile Framework).

It is expected that the Senior Engineer – Modeling and Simulation will not only collaborate heavily with internal stakeholders, but also document and communicate the underlying technical basis of the models for the benefit of and use by the broader engineering and scientific community responsible for design and manufacture of drug delivery devices.


What we expect of you

We are all different, yet we all use our unique contributions to serve patients. The professional we seek is a go getter with these qualifications.

Basic Qualifications:

  • Doctorate degree
  • Or Master’s degree and 2 years of relevant structural simulation (in-silico) experience showcasing proficiency in commercially available tools.
  • Or Bachelor’s degree and 4 years of relevant structural simulation (in-silico) experience showcasing proficiency in commercially available tools.
  • Or Associate’s degree and 8 years of relevant structural simulation (in-silico) experience showcasing proficiency in commercially available tools.
  • Or High school diploma / GED and 10 years of relevant structural simulation (in-silico) experience showcasing proficiency in commercially available tools.

Preferred Qualifications:

  • Proficiency in mathematical and computational (in-silico) modeling, FEA for structural mechanics, and multi-physics problems using commercial software such as 3DEXPERIENCE platform SIMULIA, ANSYS, LS-Dyna, COMSOL.
  • Skilled in programming in Python, and/or MATLAB for engineering purposes.
  • Experience with GitLab and/or other code/model repositories available for version control, code collaboration, and project management.
  • Knowledge of Scrum and SAFe methodologies, with a proven track record as a scrum master or product owner.
  • Experience with combination products and device regulatory requirements, medical device development and design controls, and knowledge of process controls.
  • Excellent communication, presentation, and technical documentation skills are highly desired.
  • Intellectual curiosity with ability to learn new concepts/frameworks, algorithms, and technology rapidly as needs arise.
  • Ability to manage multiple competing priorities simultaneously and work in highly collaborative, cross-functional environments.


What you can expect of us

As we work to develop treatments that take care of others, we also work to care for our teammates’ professional and personal growth and well-being.

The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.

Amgen offers a Total Rewards Plan comprising health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities including:

  • Comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts.
  • A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
  • Stock-based long-term incentives
  • Award-winning time-off plans and bi-annual company-wide shutdowns
  • Flexible work models, including remote work arrangements, where possible

Apply now | for a career that defies imagination | Objects in your future are closer than they appear. Join us.

Application deadline

External/Internal postings:

Amgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position.

Amgen is an Equal Opportunity employer and will consider you without regard to your race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.

SALARY RANGE: 114,962.00 USD - 139,704.00 USD

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